by Alan J. Cohen, M.D.
Antidepressant-induced sexual dysfunction is becoming an increasingly
common complaint amongst patients, particularly those treated
with selective serotonin reuptake inhibitors. Many pharmacological
interventions have been tried with some success, including Cyproheptadine,
Amantadine, Yohimbine, Buspirone, and Amphetamine. However, persistent
sexual dysfunction, despite these pharmacological interventions,
remains a significant problem which can affect patient compliance
and results in relapse and depression.
kIn an open trial, the effects using formulations of the extract
of ginkgo biloba were studied. All patients have been involved
in attempts to control sexual dysfunction through other pharmacological
means including the use of Periactin, Yohimbine, Amantadine and/or
Buspar. They were offered the option of continuing open trials
of different medications or of using ginkgo biloba as an alternative
to treat sexual dysfunction. All patients agreed to continue
their antidepressant medication, and all met DSM IV criteria
for a depressive disorder.
